Monogenetic Obesity. The currently known monogenetic forms of obesity are described in the chapter by Hebebrand [pp. 80–90]. The most frequent monogenetic obesity in humans is caused by a mutation in the melanocortin-4-receptor gene (MC4R). In obese populations, the prevalence of this mutation ranges at 5%, so a molecular-genetic screening may become effective in all obese subjects as soon as a causal therapy for this mutation becomes available.
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